Endocrine Abstracts

Introduction: Responsible use of healthcare resources dictates that judicious test ordering be encouraged. Although the appearance of anti-GAD antibodies is known to precede and predict the development of autoimmune diabetes, its use as a screen for risk of developing diabetes is not warranted. Results are useful in determining treatment, however, when it is difficult to distinguish type 1 from type 2 diabetes or when the probability of progression from type 2 to type 1 is hig...

Objectives: The aim of the study was to evaluate the normal reference values for thyroid uptake using Technetium-99 m (Tc-99 m) pertechnetate.Methods: Sixty-seven euthyroid patients with primary hyperparathydism who underwent parathyroid imaging with Tc-99 m pertechnetate between January 2012 to April 2014 at the Nuclear Medicine department, Newcastle upon Tyne Hospitals was studied. Electronic medical records and biochemical thyroid functi...

Objectives: The aim of the study was to evaluate the normal reference values for thyroid uptake using Technetium-99 m (Tc-99 m) pertechnetate.Methods: Sixty-seven euthyroid patients with primary hyperparathydism who underwent parathyroid imaging with Tc-99 m pertechnetate between January 2012 to April 2014 at the Nuclear Medicine department, Newcastle upon Tyne Hospitals was studied. Electronic medical records and biochemical thyroid functi...

Heat shock protein 90 (HSP90) plays a pivotal role in maturation and stabilization of proteins in conditions of stress. Many HSP90 client proteins are involved in oncogenic signaling and cancer progression, therefore HSP90 inhibitors have a potential as pharmaceutical agents. We reported a strong HSP90 overexpression in corticotroph adenomas and the treatment with C-terminal HSP90 inhibitors has potent anti-tumorigenic and anti-secretory effects in these tumors in vitro</e...

Background: We have previously demonstrated colonic expression of the endogenous GH secretagogue, ghrelin, but not the GHS-R, and that ghrelin exerts proliferative effects on colonic epithelial cells. However, whether these are specific to ghrelin, or which genes are affected in response is uncertain.Aims: Determine the specificity of the proliferative effects of ghrelin on colonic epithelial cells, and effects on mRNA levels of the cancer associated ge...

Introduction: With a prevalence of about one in 3000 newborns, congenital hypothyroidism (CH) is the leading cause of preventable mental retardation and growth failure. The objective of this work is to clarify the contribution of thyroid scintigraphy (TS) using technetium 99 m for the diagnosis of CH and this through the experience of the nuclear medicine department in Sahloul university Hospital.Materials and methods: This is a retrospective study inclu...

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Although the cause of the anovulation is unknown there are a number of endocrine candidates; hyperinsulinaemia, raised steroid production and increased levels of the sexual differentiative factor anti-Müllerian hormone (AMH). The latter is increasingly thought to be an inhibitor of folliculogenesis. Hyperinsulinaemia in PCOS is now widely treated with metformin and we have shown that thi...

Introduction: The current epidemic of Type 2 Diabetes Mellitus (T2DM) and obesity is positively correlated with a rise in consumption of high-fructose syrups and refined carbohydrates. Recent reports have showed that feeding rodent a high-fructose diet leads to insulin resistance, glucose intolerance and dyslipidaemia. Nevertheless, its mitochondrial effects has not been fully studied yet.Aim: We decided to explore the alterations in mitochondrial bioene...

Background and Aim: Klinefelter syndrome (47,XXY; KS) is a very common chromosomal disorder, affecting 1:600 men. Klinefelter men have been described to exhibit clinically relevant metabolic patterns related to a pro-inflammatory status, resulting in a high prevalence of insulin resistance and cardiovascular impairment. Testosterone deficiency in form of primary hypogonadism is a common feature in these men.EXAKT (epigenetics, X-chromosomal features and ...

CNP, the third peptide of the mammalian natriuretic peptide family, exerts its biological effects through activation of the guanylyl cyclase B (GC-B) receptor and resulting cGMP accumulation. Our previous studies reported that CNP stimulates phosphorylation of MAPK family proteins in GH3 somatotrophs. This present study aimed to further characterise the mechanism of CNP-stimulated ERK phosphorylation and resulting biological consequences in GH3 cells. Western blot analyses sho...